Reduces hunger & cravings
Berberine supports your body’s natural satiety signaling, helping you feel satisfied and manage everyday cravings.
4.4 · 59 verified reviews
GLP-1 Activator
Two standardized berberine extracts support the body’s AMPK metabolic pathway and healthy appetite regulation, to help you manage hunger, cravings & weight as part of a healthy lifestyle.
- 86% of survey participants reported losing weight over 12 weeks*
- Key ingredients studied in 50+ published papers
- Supports the body’s own satiety signaling
- Supports AMPK metabolic activity
- Supports healthy cellular energy metabolism
What's in your subscription
- 30-day money-back guarantee
- Flexible delivery and easy cancellation anytime
- Free shipping on subscriptions
The 30-Day Guarantee
If you don't feel more regular and comfortable within 30 days, we'll refund every penny.
How do I take it?
Take 2 capsules daily with 6–8 oz of water, ideally with your largest meal to support healthy digestion and metabolism. If you take any medication, check with your healthcare provider before adding a new supplement.
Can I take this with other medications?
Berberine can affect blood sugar and may interact with some medications. Our formula was reviewed by our medical advisory board, but everyone’s situation is different — please share the supplement facts panel with your prescriber and get their okay before starting if you take any prescription medication.
When will I see results?
Most members notice fewer cravings and steadier energy within the first 7–14 days. Changes in appetite and weight, as part of a healthy diet and routine, typically become noticeable around week 4–8. Individual results vary.
What are the key ingredients?
800 mg of high-purity Berberine HCl per serving — a dual bark/root extract for full-spectrum potency — delivered with L-Leucine and Olive Oil to boost berberine’s notoriously low absorption. No fillers, no fairy dust. Full supplement facts panel is in the gallery above.
Certificate of Analysis & Testing
Every minome product lot is third-party tested under our 5-Point Testing Program: presence of heavy metals in raw material, assay of active ingredient in raw material, assay of active ingredient in finished product, fill weight in finished product, and presence of heavy metals in finished product.
- Formulated by an MD
- Research-Backed Ingredients
- 3rd-Party Tested
- Made in the USA · cGMP
- Happiness Guaranteed
A natural approach to metabolic health
Berberine is one of the most-studied botanicals for metabolic support. It works with your body’s own systems — supporting the AMPK metabolic pathway, healthy appetite regulation, and overall metabolic wellness as part of a balanced lifestyle.
Explore the research
Fires up your metabolism
Berberine supports the AMPK pathway, helping your metabolism convert stored fuel into steady everyday energy.
Supports glucose metabolism
Helps support healthy glucose metabolism already in the normal range, as part of a balanced diet and lifestyle.
Supports metabolic wellness
Berberine supports overall metabolic wellness and complements a heart-healthy diet and an active lifestyle.
Customer-Reported Results. Third-Party Tested.
89%
Decreased appetiteOf participants reported reduced hunger and fewer cravings*
86%
Lose WeightOf participants reported losing weight over 12 weeks*
70%
Steadier EnergyOf participants reported steadier energy between meals*
62%
Fewer CravingsOf participants reported fewer sugar cravings day to day*
*Based on a self-reported consumer survey of 2,930 minome customers, March 2026. Individual results vary.
Not all berberine is the same.
Most berberine barely absorbs and hides its dose in a blend. minome uses a disclosed 800 mg dual-extract dose in a delivery system built for absorption.
Typical berberineoff-the-shelf
minome ActivatorBiCapsa® delivery
Dose disclosed
Dose disclosed
Often hidden in a blend
Full 800 mg dose on the label
Absorption
Absorption
Notoriously poorly absorbed
BiCapsa® built for better uptake
Transparency
Transparency
Source often unclear
Clear, fully-disclosed formula
Extract type
Extract type
Single generic extract
Dual bark & root extract blend
Testing
Testing
Rarely third-party tested
5-point third-party lot testing
Guarantee
Guarantee
Usually final sale
30-day money-back guarantee
4.4 · 59 reviews
Real Reviews From minome Customers
![Photo from [PLACEHOLDER — replace with real verified review]](/images/activator/testimonial-1.webp)
“I was skeptical about berberine, but it slots into my morning routine easily. A few weeks in, my usual afternoon cravings are much easier to manage.”
[PLACEHOLDER — replace with real verified review]Verified
![Photo from [PLACEHOLDER — replace with real verified review]](/images/activator/testimonial-2.webp)
“What I like most is the transparency — the full dose is right on the label. It’s become a simple part of my daily wellness routine.”
[PLACEHOLDER — replace with real verified review]Verified
![Photo from [PLACEHOLDER — replace with real verified review]](/images/activator/testimonial-3.webp)
“Two capsules with my biggest meal and that’s it. Vegan, third-party tested, and it hasn’t bothered my stomach the way I’d worried it might.”
[PLACEHOLDER — replace with real verified review]Verified
![Photo from [PLACEHOLDER — replace with real verified review]](/images/activator/testimonial-4.webp)
“I’ve tried other berberine supplements that felt like a gamble. This one absorbs better for me and I’ve stuck with it longer than any before.”
[PLACEHOLDER — replace with real verified review]Verified
![Photo from [PLACEHOLDER — replace with real verified review]](/images/activator/testimonial-5.webp)
“Easy to keep up with, and no jitters since it’s stimulant-free. A clean addition to the healthy habits I’m working on.”
[PLACEHOLDER — replace with real verified review]Verified
Potency you can feel.
An 800 mg serving of high-purity berberine, refined into a delivery system engineered to solve its biggest limitation: absorption.
Phellodendron amurense
Berberine HCl
A broad-spectrum 8% bark & root extract that delivers berberine alongside the plant’s natural cofactors. This 790 mg dose sits in the range used in berberine research on AMPK activity, satiety signaling, and healthy glucose metabolism.
AMPK activatorGLP-1 supportClinically studied
Berberis aristata
Berberine HCl
An ultra-concentrated 97% bark isolate that adds pure alkaloid potency on top of the broad-spectrum extract. Layering this standardized isolate alongside the whole-plant extract gives a richer, more complete activation profile no one powder can match.
AMPK activatorGLP-1 supportUltra-concentrated
Olive Oil + L-Leucine Delivery
Bioavailability matrix
Berberine is famously hard to absorb. We suspend it in olive oil and pair it with L-Leucine to carry more of every milligram into your bloodstream — so the dose on the label is the dose your body actually gets.
Better uptakeClean carriersVegan
Vegan
Allergen Free
GMO Free
Gluten Free
GMP Certified
BiCapsa® Technology
Every Activator capsule is built to actually absorb.
Berberine is notoriously hard to absorb. BiCapsa® carries it past stomach acid — for dramatically better uptake.
Outer capsule
An acid-resistant outer shell shields the berberine so none is wasted before it can work.
Inner capsule
Releases the full dose lower in the gut, where berberine is absorbed and put to work.
Meet the Experts Behind The minome Formula
Our Scientific Advisory Board unites leading minds from Georgetown, Johns Hopkins, and the University of Victoria — collaborating to hold every minome formula to the cutting edge of metabolic and microbiome science.
Dr. Marc R. Blackman, MD
Endocrinologist & Physician-Scientist, Professor of Medicine at Georgetown & Johns Hopkins
Dr. Nancy M. Sherwood
PhD, Comparative Neuroendocrinologist, Professor of Biology at the University of Victoria
Harmandeep Singh, MD
Board Certified Physician, Metabolism & Anti-Aging Specialist
How does this work to support my metabolism?
Berberine works with your body’s own metabolic machinery — supporting the AMPK pathway (a key metabolic regulator), healthy appetite signaling, and glucose metabolism already in the normal range. Used consistently as part of a healthy routine, it supports steady, everyday metabolic wellness.
Can I take this with other medications?
Berberine is one of the most-studied botanicals for metabolic health, and our formula was reviewed by our medical advisory board. Because berberine can affect blood sugar, please share the supplement facts with your prescriber and get their okay before starting if you take any medication.
When will I notice results?
Most members feel fewer sugar cravings and steadier energy within the first 7–14 days. Changes in appetite and weight, as part of a healthy routine, typically become noticeable by week 4–8. Individual results vary.
How and when do I take it?
Take 2 capsules daily with 6–8 oz of water, ideally with your largest meal to support digestion and metabolism. It’s stimulant-free, so timing is flexible — many members split one capsule with lunch and one with dinner.
What’s actually in it?
800 mg of high-purity Berberine HCl per serving — a dual bark/root extract for full-spectrum potency — delivered in olive oil with L-Leucine to maximize absorption. Vegan capsule, no fillers, no proprietary blends. The complete supplement facts panel is in the gallery above.